Efficient synthesis of spiro diheterocycles <i>via</i> multi-component dicyclization reaction.
Lingfeng WangPeng ZhaoSong LiYongmin MaPengfei ZhangWeiming XuPublished in: Organic & biomolecular chemistry (2022)
A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2'-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two heterocycles and one valuable quaternary carbon in one pot <i>via</i> an <i>in situ</i> cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.