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Recommendations for robust and reproducible preclinical research in personalised medicine.

Vibeke FosseEmanuela OldoniFlorence BietrixAlfredo BudillonEvangelos P DaskalopoulosMaddalena FratelliBjörn GerlachPeter M A GroenenSabine M HölterJulia M L MenonAli MobasheriNikki OsborneMerel Ritskes-HoitingaBettina RyllElmar SchmittAnton UssiAntonio L AndreuEmmet McCormacknull null
Published in: BMC medicine (2023)
Appropriate preclinical models should be an integral contributor to interventional clinical trial success rates, and predictive translational models are a fundamental requirement to realise the dream of personalised medicine. The implementation of these guidelines is ambitious, and it is only through the active involvement of all relevant stakeholders in this field that we will be able to make an impact and effectuate a change which will facilitate improved translation of personalised medicine in the future.
Keyphrases
  • clinical trial
  • clinical practice
  • primary care
  • healthcare
  • cell therapy
  • stem cells
  • randomized controlled trial
  • open label
  • phase ii
  • quality improvement
  • double blind