Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.

Iqra NazishAdamantios MamaisAnna MallachConceicao BettencourtAlice KaganovichThomas Treharne WarnerJohn HardyPatrick A LewisJennifer PocockMark R Cookson Rina Bandopadhyay

Published in: bioRxiv : the preprint server for biology (2023)

Overall, these results suggest that microglial LRRK2 may contribute to PD pathogenesis through altered inflammatory pathways. Our findings should encourage future investigations of these putative avenues in the context of PD pathogenesis.

Keyphrases

gene expression
inflammatory response
neuropathic pain
dna methylation
oxidative stress
current status
lipopolysaccharide induced
lps induced