Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging.
Lorraine J LauwerendsBo E ZweedijkHidde A GalemaLisanne K A NeijenhuisNeeltje G Dekker-EnsinkRobert J Baatenburg de JongCornelis VerhoefShadhvi S BhairosinghPeter J K KuppenAlexander L VahrmeijerTessa M van GinhovenSenada KoljenovićSjors A KoppesDenise E HillingStijn KeereweerPublished in: Molecular diagnosis & therapy (2024)
This study highlights integrin αvβ6 and EGFR as viable FLI targets in OSCC and LSCC, especially integrin αvβ6 for tumour margin delineation. In PTC, despite lower expressions, the significant overexpression of VEGF-α, c-MET, and EGFR suggests their potential as FLI targets. Our findings support the development of tumour-targeted FLI tracers to improve surgical precision in HNC.