Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.

Ryan J DuchatelAbdul MannanAmeha S WolduTom HawtreyPhoebe A HindleyAlicia M DouglasEvangeline R JacksonIzac J FindlayZacary P GermonDilana StaudtPadraic S KearneyNathan D SmithKate E HindleyJason E CainNicolas AndréAndres Morales La MadridBrett NixonGeoffry N De IuliisJavad NazarianKathleen IrishFrank AlvaroDavid D EisenstatAlexander BeckNicholas A VitanzaRomain MuellerJonathan C MorrisMatthew D Dun

Published in: Neuro-oncology advances (2021)

This study confirms the biological activity of GsONC201 and documents the OS of patients who received the drug; however, GsONC201 was never used as a monotherapy.

Keyphrases

clinical evaluation
combination therapy
low grade
randomized controlled trial
emergency department
open label
cell therapy
stem cells
bone marrow
mesenchymal stem cells
study protocol
electronic health record