The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.
Sami QadriSusanna Lallukka-BrückPanu K LuukkonenYou ZhouFrancesco RubinoMarju Orho-MelanderHenna SammalkorpiAnne JuutiAnne K PenttiläJulia PerttiläAntti HakkarainenTiina E LehtimäkiMatej OresicTuulia HyötyläinenLeanne HodsonVesa M OlkkonenHannele Yki-JärvinenPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Contrary to previous assumptions, PNPLA3 is highly abundant in AT. PNPLA3-I148M locally remodels AT TGs to become polyunsaturated as it does in the liver, without affecting lipolysis or composition of serum NEFAs. Changes in AT metabolism do not contribute to NAFLD in PNPLA3-I148M carriers.