Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes.
Samira Taghizadeh JazdaniHajieh Bibi ShahbazianBahman CheraghianMohammad Taha JalaliNarges MohammadtaghvaeiPublished in: BMC research notes (2021)
The distribution of PCSK9 rs615563 genotypes was not significantly different between the diabetic and non-diabetic individuals. The incidence of diabetes after five-years of follow-up was not different between the genotypes. Our findings also showed no significant relationship between this polymorphism and serum lipid parameters. The data extracted from our cohort study do not support the findings that the gain-of-function mutations of PCSK9 predispose to the incidence of type 2 diabetes.
Keyphrases
- type diabetes
- glycemic control
- risk factors
- low density lipoprotein
- cardiovascular disease
- wound healing
- fatty acid
- copy number
- insulin resistance
- electronic health record
- genome wide
- weight loss
- dna methylation
- skeletal muscle
- metabolic syndrome
- artificial intelligence
- data analysis
- genome wide identification
- genome wide analysis