Necessary Role of Acute Ceramide Formation in The Human Microvascular Endothelium During Health and Disease.

Gopika SenthilKumar Boran KatunaricZachary ZirgibelBrian LindemerMaria J Jaramillo-TorresHenry Bordas-MurphyMary E SchulzPaul J PearsonJulie K Freed

Published in: bioRxiv : the preprint server for biology (2023)

These data suggest that despite key differences in downstream signaling between health and disease, acute NSmase-mediated ceramide formation and its subsequent conversion to S1P is necessary for proper functioning of the human microvascular endothelium. As such, therapeutic strategies that aim to significantly lower ceramide formation may prove detrimental to the microvasculature.

Keyphrases

endothelial cells
liver failure
public health
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nitric oxide
respiratory failure
induced pluripotent stem cells
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mental health
drug induced
intensive care unit
aortic dissection
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