Harsh parenting and non-suicidal self-injury in adolescence: the mediating effect of depressive symptoms and the moderating effect of the COMT Val158Met polymorphism.

Jinmeng LiuXia LiuHui WangYemiao Gao

Published in: Child and adolescent psychiatry and mental health (2021)

Genetic variations of COMT Val158Met may be a critical candidate in understanding the development of depression and NSSI. We conclude that Val homozygotes of the COMT Val158Met polymorphism play a role in susceptibility to both depressive symptoms and NSSI.

Keyphrases

depressive symptoms
social support
tyrosine kinase
sleep quality
genome wide
gene expression
copy number