Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma.

Md Gulam Musawwir KhanAmit GhoshBhavesh VariyaMadanraj Appiya SantharamAwais Ullah IhsanSheela RamanathanSubburaj Ilangumaran

Published in: BMC cancer (2020)

SOCS1 expression in HCC has an independent prognostic value whereas SOCS3 expression does not. The predictive potential of SOCS1 expression is increased when combined with other oncogenic signaling pathway genes.

Keyphrases

poor prognosis
signaling pathway
pi k akt
binding protein
genome wide
epithelial mesenchymal transition
transcription factor
long non coding rna
dna methylation
gene expression
cell proliferation
oxidative stress
risk assessment
genome wide identification