Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers.
Robert B ScharpfArchana BalanBiagio RicciutiJacob FikselChristopher M CherryChenguang WangMichele L LeNoue-NewtonHira A RizviJames Robert WhiteAlexander S BarasJordan AnayaBlair V LandonMarta Majcherska-AgrawalPaola GhanemJocelyn LeeLeon RaskinAndrew S ParkHuakang TuHilary K HsuKathryn C ArbourMark M AwadGregory J RielyChristine M LovlyValsamo AnagnostouPublished in: Cancer research (2022)
The complex genomic landscape of RAS-mutant tumors is reflective of selection processes in a cancer lineage-specific and context-dependent manner, highlighting differential therapeutic vulnerabilities that can be clinically translated.