The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

Kezia C L WhatleyGilda PadalinoHelen WhitelandKathrin K GeyerBenjamin J HulmeIain W ChalmersJosephine Forde-ThomasSalvatore FerlaAndrea BrancaleKarl F Hoffmann

Published in: PLoS neglected tropical diseases (2019)

Collectively, these results provide further support for the development of next-generation drugs targeting schistosome epigenetic pathway components. In particular, the progression of histone methylation/demethylation modulators presents a tractable strategy for anti-schistosomal control.

Keyphrases

dna methylation
genome wide
small molecule
gene expression
cancer therapy
living cells
drug delivery
photodynamic therapy