Suppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation.

Anne Hald RittigClaus JohansenPamela CelisNiels OdumThomas LitmanAnders WoetmannLise M LindahlLars Iversen

Published in: Experimental dermatology (2020)

Upregulation of miR-195-5p in MF inhibits cycle arrest by downregulation of ARL2. miR-195-5p may thus function as a tumor suppressor in MF and low miR-195-5p expression in lesional MF skin may promote disease progression.

Keyphrases

cell proliferation
poor prognosis
cell cycle
long non coding rna
signaling pathway
binding protein
pi k akt
soft tissue