SeXY chromosomes and the immune system: reflections after a comparative study.
Irene MeesterEdgar Manilla-MuñozRafael B R León-CachónGustavo A Paniagua-FraustoDiego Carrión-AlvarezC Orelli Ruiz-RodríguezXimena Rodríguez-RangelJoyce M García-MartínezPublished in: Biology of sex differences (2020)
The X chromosome is not enriched for ISRG, though particular X-linked genes may be responsible for sex differences in certain immune responses. So far, there is insufficient information on sex-biased expression of X/Y-linked ISRG in leukocytes to draw general conclusions on the impact of X/Y-linked ISRG in immune function. More research on the regulation of the expression X-linked genes is required with attention to 1) female and male mechanisms that may either augment or diminish sex biased expression and 2) tissue-specific expression studies.