High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.

Alexander C Bashore Hanying YanChenyi XueLucie Y Zhu Eunyoung KimThomas MawsonJohana Coronel Allen Chung Nadja SachsSebastian HoLeila S RossMichael KissnerEmmanuelle PassegueRobert C BauerLars Maegdefessel Mingyao LiMuredach P Reilly

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.

Keyphrases

single cell
cardiovascular disease
rna seq
endothelial cells
high throughput
induced pluripotent stem cells
pain management
type diabetes
high resolution
genome wide
metabolic syndrome
gene expression
cardiovascular events
bone marrow
dna methylation
stem cells
chronic pain
high density