Pelvic lymph-node staging with 18F-DCFPyL PET/CT prior to extended pelvic lymph-node dissection in primary prostate cancer - the SALT trial.
B H E JansenYves J L BodarG J C ZwezerijnenD MeijerJ P van der VoornJ A NieuwenhuijzenM WondergemT A RoeleveldR BoellaardO S HoekstraR J A van MoorselaarD E Oprea-LagerA N VisPublished in: European journal of nuclear medicine and molecular imaging (2020)
18F-DCFPyL PET/CT showed a high specificity (94.4%), yet a limited sensitivity (41.2%) for the detection of pelvic lymph-node metastases in primary PCa. This implies that current PSMA PET/CT imaging cannot replace diagnostic ePLND. Further research is necessary to define the exact place of PSMA PET/CT imaging in the primary staging of PCa.