Gastric cancer with microsatellite instability displays increased thymidylate synthase expression.
Marina Alessandra PereiraAndre Roncon DiasMarcus Fernando Kodama Pertille RamosLeonardo CardiliRafael Dyer Rodrigues de MoraesBruno ZilbersteinSergio Carlos NahasEvandro Sobroza de MelloUlysses RibeiroPublished in: Journal of surgical oncology (2022)
MSI GC was associated with high TS levels, which may explain therapeutic resistance to 5-FU. Additionally, MSI + TS-high showed better survival, but without improvement with CMT.
Keyphrases