Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics.
Florian HeinkelMeghan M VerstraeteSiran CaoJanessa LiPatrick FarberElizabeth StangleBegonia Silva-MorenoFangni PengSurjit DixitMartin J BoulangerThomas Spreter Von KreudensteinEric Escobar-CabreraPublished in: mAbs (2022)
CE-SDS: capillary electrophoresis sodium dodecyl sulfate; DSC: differential scanning calorimetry; FACS: fluorescence-activated cell sorting; FSA: full-sized antibody; Her2: human epidermal growth factor receptor 2; MFI: mean fluorescent intensity; OAA: one-armed antibody; PBS: phosphate-buffered saline; PDB: Protein Data Bank; SEC: size-exclusion chromatography; prepSEC (preparative SEC); RMSD: root-mean-square deviation; RU: resonance units; SPR: surface plasmon resonance; TAA: tumor-associated antigen; WT: wild-type.
Keyphrases
- energy transfer
- epidermal growth factor receptor
- capillary electrophoresis
- wild type
- mass spectrometry
- quantum dots
- tyrosine kinase
- advanced non small cell lung cancer
- endothelial cells
- high resolution
- single cell
- liquid chromatography
- electronic health record
- small molecule
- high speed
- cell therapy
- induced pluripotent stem cells
- living cells
- high performance liquid chromatography
- high intensity
- pluripotent stem cells
- amino acid
- stem cells
- electron microscopy
- machine learning
- binding protein