Schwann Cells and Myelin in Human Peripheral Nerve: Major Protein Components Vary with Age, Axon Size and Pathology.
Alan PestronkRobert E SchmidtRobert C BucelliJulia SimPublished in: Neuropathology and applied neurobiology (2023)
Peripheral nerve SC and myelin have varied molecular phenotypes, related to age, axon size and nerve pathology. In normal adult peripheral nerve, myelin has two different patterns of molecular composition. MBP is mostly absent from myelin around a population of intermediate-sized axons, while P0 is present in myelin around all axons. Denervated SC have a molecular signature that differs from normal SC types. With acute denervation, SC may stain for both NCAM and MBP. Chronically denervated SC often stain for both NCAM and P0.
Keyphrases
- peripheral nerve
- white matter
- induced apoptosis
- endothelial cells
- single molecule
- multiple sclerosis
- oxidative stress
- drug induced
- small molecule
- cell proliferation
- respiratory failure
- signaling pathway
- endoplasmic reticulum stress
- binding protein
- protein protein
- amino acid
- acute respiratory distress syndrome
- mechanical ventilation
- pluripotent stem cells