Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum , a Red Sea Soft Coral.
Tarik A MohamedAbdelsamed A ElshamyMohamed H Abd El-RazekAsmaa M Abdel-TawabSherin K AliMohamed AboelmagdMidori SuenagaPaul W ParéAkemi UmeyamaMohamed-Elamir F HegazyPublished in: Molecules (Basel, Switzerland) (2022)
Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea-derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F ( 1 ) and G ( 2 ), as well as four identified analogues ( 3 - 6 ) together with a furan derivate ( 7 ) were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F ( 1 ) contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites ( 1 - 7 ) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound 4 exhibited an IC 50 56 µM and 55 µM against A549 and HSC-2 cells, respectively.
Keyphrases
- drug discovery
- molecular docking
- infectious diseases
- cell cycle arrest
- structure activity relationship
- induced apoptosis
- papillary thyroid
- magnetic resonance
- oxidative stress
- high resolution
- ms ms
- cell death
- electronic health record
- big data
- pi k akt
- machine learning
- squamous cell
- randomized controlled trial
- signaling pathway
- magnetic resonance imaging
- systematic review
- anti inflammatory
- artificial intelligence
- solid state
- solar cells