Clinical and molecular characteristics of patients with brain metastasis secondary to pancreatic ductal adenocarcinoma.
Mahmoud M G YousefMark W HurdAbdelrahman YousefEthan Bernard LudmirAshwathy B PillaiJennifer PetersonEugene Jon KoaySali AlbaroukiChing-Wei TzengRebecca SnyderMatthew H G KatzHuamin WangMichael J OvermanAnirban MaitraShubham PantBrandon G SmagloRobert A WolffJames YaoJohn P ShenDan ZhaoPublished in: The oncologist (2024)
Br-M is a late PDAC complication, resulting in an extremely poor prognosis especially in leptomeningeal disease. KRAS was mutated in 94.1% of the patients and the KRASG12V subtype was prevalent.