Regulatory roles of extracellular vesicles in adverse pregnancy outcomes exposed with environmental toxicants.
Xiaoqing WangShukun WanChenyang MiWenxin HuangRong WangHuidong ZhangPublished in: Critical reviews in toxicology (2023)
Extracellular vesicles (EVs) derived from parental cells could communicate with neighboring or distant recipient cells. The components in EVs, especially non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, could regulate the functions of the recipient cells. Meanwhile, EVs could also be used as valuable biomarkers and drug delivery carriers. Moreover, environmental toxicants may alter EVs components and regulate EVs-mediated pathogenesis of various diseases. In this review, we mainly summarized the roles of EV-derived non-coding RNAs in the regulation of cell dysfunctions in various adverse pregnancy outcomes, such as preeclampsia (PE), gestational diabetes mellitus (GDM), and miscarriage. Moreover, the effects of environmental toxicants on the components and functions of EVs, as well as on their regulatory roles in these diseases, were also discussed.
Keyphrases
- pregnancy outcomes
- induced apoptosis
- pregnant women
- cell cycle arrest
- drug delivery
- long non coding rna
- endoplasmic reticulum stress
- poor prognosis
- cell death
- oxidative stress
- signaling pathway
- emergency department
- early onset
- mesenchymal stem cells
- pi k akt
- human health
- bone marrow
- cell proliferation
- risk assessment
- climate change