Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation.
Luca CassettaKirsten BruderekJoanna Skrzeczynska-MoncznikOktawia OsieckaXiaoying HuIda Marie RundgrenAng LinKim SantegoetsUtku HorzumAna Godinho-SantosGennadiy ZelinskyyThalia Garcia-TellezSunčica BjelicaBartłomiej TaciakAstrid Olsnes KittangBenedikt HöingStephan LangMichael DixonVerena MüllerJochen Sven UtikalDerya KarakoçKerim Bora YilmazEmilia GórkaLubomir BodnarOlympia Evdoxia AnastasiouChristine BourgeoisRobert BaduraMonika Kapinska-MrowieckaMirjana GoticMark Ter LaanEsther Kers-RebelMagdalena KrólJuan Francisco SantibañezMichaela Müller-TrutwinUlf DittmerAna Espada de SousaGüneş EsendağlıGosse J AdemaKarin LoréElisabeth ErsværViktor UmanskyJeffrey W PollardJoanna CichySven BrandauPublished in: Journal for immunotherapy of cancer (2021)
This study provides improved technical protocols and workflows for the multi-center analysis of circulating human MDSC subsets. Application of these workflows revealed a predominant expansion of PMN-MDSC in solid tumors that exceeds expansion in chronic infection and inflammation.