Topiramate is more effective than acetazolamide at lowering intracranial pressure.
William J ScottonHannah F BotfieldConnar Stanley James WestgateJames L MitchellAndreas YiangouMaria S UldallRigmor H JensenAlex J SinclairPublished in: Cephalalgia : an international journal of headache (2018)
Our in vivo studies demonstrated that both subcutaneous and oral administration of topiramate significantly lowers intracranial pressure. Other drugs tested, including acetazolamide, did not significantly reduce intracranial pressure. Future clinical trials evaluating the efficacy and side effects of topiramate in idiopathic intracranial hypertension patients would be of interest.