Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5.
Hao-Yu DongYuan WangXiao-Yu ZhangMeng ZhangLong-He YangZheng-Biao ZouYou LiMing-Min XieXian-Wen YangBin WangPublished in: Chemistry & biodiversity (2024)
Three new C 10 and C 12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC 50 value of 120.3 nM.
Keyphrases
- lps induced
- high resolution
- inflammatory response
- nitric oxide
- fatty acid
- induced apoptosis
- cell cycle arrest
- magnetic resonance
- lipopolysaccharide induced
- electronic health record
- photodynamic therapy
- nitric oxide synthase
- big data
- hydrogen peroxide
- high speed
- endoplasmic reticulum stress
- mass spectrometry
- machine learning
- cell death
- solid state
- artificial intelligence
- signaling pathway
- cell proliferation
- data analysis