Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.

Jason K SaNakho ChangHye Won LeeHee Jin ChoMichele CeccarelliLuigi CeruloJinlong YinSung Soo KimFrancesca P CarusoMijeong LeeDonggeon KimYoung Taek OhYeri LeeNam-Gu HerByeongkwi MinHye-Jin KimDa Eun JeongHye-Mi KimHyunho KimSeok ChungHyun Goo WooJeongwu LeeDoo-Sik KongHo Jun SeolJung-Il LeeJinho KimWoong-Yang ParkQianghu WangErik P SulmanAmy B HeimbergerMichael LimJong Bae ParkAntonio IavaroneRoel G W VerhaakDo-Hyun Nam

Published in: Genome biology (2020)

Collectively, our study characterizes the global transcriptional profile of TAMs driving mesenchymal GBM pathogenesis, providing potential therapeutic targets for improving the effectiveness of GBM immunotherapy.

Keyphrases

transcription factor
stem cells
bone marrow
gene expression
randomized controlled trial
systematic review
heat shock
risk assessment
climate change
human health