Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.

Jian ZuoQin YinLin WangWen ZhangYan FanYu-Yan ZhouYan LiGuo-Dong Wang

Published in: Pharmaceutical biology (2019)

MAN protected joints from destruction in CIA rats and exerted synergistic effects with methotrexate by improving immune microenvironment. The combination regimen could bring additional benefits to rheumatoid arthritis patients.

Keyphrases

rheumatoid arthritis patients
high dose
rheumatoid arthritis
stem cells
disease activity
high glucose
low dose
drug delivery