Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Autoimmune Thyroid Disease.
Anello Marcello PomaSarah Salehi HammerstadAngelo GenoniAlessio BasoloKnut Dahl-JørgensenAntonio TonioloPublished in: Microorganisms (2021)
As in the case of EV strains obtained from autoimmune diabetes, results show that the EV strains that are present in the thyroid of AITD cases do repress IFN and cytokine pathways. JAK1/STAT1 upregulation supports activation of TLR pathways and aberrant T cell signaling. In the early phases of AITD, our results highlight the potential benefit of interventions aimed at blocking the viral infection and easing the inflammatory response.
Keyphrases
- inflammatory response
- escherichia coli
- multiple sclerosis
- induced apoptosis
- toll like receptor
- type diabetes
- immune response
- lipopolysaccharide induced
- gene expression
- cardiovascular disease
- physical activity
- lps induced
- signaling pathway
- poor prognosis
- genome wide
- rna seq
- drug induced
- single cell
- adipose tissue
- oxidative stress
- risk assessment
- glycemic control
- insulin resistance
- skeletal muscle
- climate change