PTEN expression and morphological patterns in prostatic adenocarcinoma.

Andrew J SpiekerJennifer B GordetskyAlexander S MarisLauren M DehanJames E DenneyShanna A Arnold EgloffKristen ScarpatoDaniel A BarocasGiovanna A Giannico

Published in: Histopathology (2021)

PTEN loss within glomeruloid pattern was associated with BCR. The presence of any cribriform pattern was associated with BCR, despite PTEN loss not significantly associated with invasive cribriform carcinoma. We speculate that other drivers independent from PTEN loss may contribute to poor prognostic features in cribriform carcinoma.

Keyphrases

pi k akt
cell proliferation
acute lymphoblastic leukemia
signaling pathway
poor prognosis
chronic myeloid leukemia
prostate cancer
long non coding rna