PTEN expression and morphological patterns in prostatic adenocarcinoma.
Andrew J SpiekerJennifer B GordetskyAlexander S MarisLauren M DehanJames E DenneyShanna A Arnold EgloffKristen ScarpatoDaniel A BarocasGiovanna A GiannicoPublished in: Histopathology (2021)
PTEN loss within glomeruloid pattern was associated with BCR. The presence of any cribriform pattern was associated with BCR, despite PTEN loss not significantly associated with invasive cribriform carcinoma. We speculate that other drivers independent from PTEN loss may contribute to poor prognostic features in cribriform carcinoma.