Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats.

Yue-Tong Liu Ye Yang Qin Wang Apaer Kahaer Jiyun Zhang Jing Liao Mairemugu Abudureyimu Reyila Yahefu Jing Qi Lei Zhao Jun Zhu

Published in: International journal of endocrinology (2019)

TGF-β1 can decrease the expression of miR-130b in kidney tissues of DN rats. Moreover, miR-130b may be involved in the protective effect of 1,25(OH)2D3 on renal fibrosis via TGF-β1.

Keyphrases

diabetic nephropathy
transforming growth factor
poor prognosis
diabetic rats
gene expression
high fat diet
binding protein
transcription factor
high glucose
oxidative stress
type diabetes
long non coding rna
adipose tissue
endothelial cells
insulin resistance
skeletal muscle
signaling pathway
liver fibrosis