Limited added value of laboratory monitoring in thiopurine maintenance monotherapy in inflammatory bowel disease patients.

Joany E KreijneAnnemarie C de VriesRozanne C de VeerGerd BoumaGerard DijkstraMichiel D VoskuilRachel WestSofia A W van MoorselDirk J de JongNanne K de BoerC Janneke van der Woudenull null

Published in: Alimentary pharmacology & therapeutics (2020)

Severe laboratory toxicity is uncommon after 1 year of thiopurine monotherapy at 4-month monitoring intervals. Therapy adjustments are rare after detection of laboratory toxicity. After 1 year of thiopurine monotherapy, laboratory monitoring may be lowered to less than a 4-month interval.

Keyphrases

combination therapy
end stage renal disease
open label
ejection fraction
chronic kidney disease
oxidative stress
newly diagnosed
prognostic factors
peritoneal dialysis
randomized controlled trial
clinical trial
patient reported outcomes
study protocol