Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation.

Julian SchwärzlerLisa MayrBernhard RadlingerFelix GrabherrMaureen PhilippBernhard TexlerChristoph GranderAndreas RitschMonika HunjadiBarbara EnrichKarin SalzmannQitao RanLukas A HuberHerbert TilgSusanne KaserTimon Erik Adolph

Published in: International journal of obesity (2005) (2022)

Adipocyte GPX4 protects against spontaneous metabolic dysregulation and systemic low-grade inflammation independent from ferroptosis, which could be therapeutically exploited in the future.

Keyphrases

insulin resistance
low grade
adipose tissue
oxidative stress
high grade
high fat diet
metabolic syndrome
skeletal muscle
fatty acid
polycystic ovary syndrome
cell death
type diabetes
high fat diet induced
current status
glycemic control
drug induced