Fibrosis as a Risk Factor for Cutaneous Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa: A Systematic Review.
Brenda Lamônica Rodrigues de AzevedoGabriel Marim RoniRosalie Matuk Fuentes TorrelioLetícia Nogueira da Gama-de-SouzaPublished in: Journal of pediatric genetics (2023)
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe subtype of epidermolysis bullosa caused by changes in collagen VII with a high risk of early development of cutaneous squamous cell carcinoma (cSCC). This review aimed to discuss the relationship between the recurrent healing process, the appearance of fibrosis, and malignant epithelial transformation in RDEB. We searched PubMed, the Regional Portal of the Virtual Health Library, and Embase for articles on the relationship between blistering, recurrent scarring, and fibrosis in the context of cSCC and RDEB. That alterations of collagen VII result in blister formation, scar deficiency associated with inflammation, and increased expression of transforming growth factor β. These events promote the differentiation of myofibroblasts and the expression of profibrotic proteins, leading to structural changes and the establishment of a microenvironment favorable to carcinogenesis. Patients with RDEB and areas of recurrent scarring and fibrosis may be more prone to the development of cSCC.
Keyphrases
- squamous cell carcinoma
- transforming growth factor
- poor prognosis
- healthcare
- epithelial mesenchymal transition
- wound healing
- public health
- oxidative stress
- liver fibrosis
- stem cells
- binding protein
- intellectual disability
- lymph node metastasis
- autism spectrum disorder
- early onset
- radiation therapy
- health information
- risk assessment
- rectal cancer
- climate change
- tissue engineering