HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0.

Niko HenselVerena RakerBenjamin FörthmannNora Tula DeteringSabrina KubinskiAnna BuchGeorgios Katzilieris-PetrasJulia SpanierViktoria GudiSylvia WagenknechtVerena KopfnagelThomas Andreas WerfelMartin StangelAndreas BeinekeUlrich KalinkeSøren Riis PaludanBeate SodeikPeter Claus

Published in: Journal of neuroinflammation (2019)

HSV-1 uses the viral protein ICP0 for the induction of FGF-expression in CNS cells. Thus, we propose that HSV-1 triggers FGF activity in the CNS for a modulation of tissue response upon infection.

Keyphrases

induced apoptosis
cell cycle arrest
herpes simplex virus
binding protein
blood brain barrier
poor prognosis
sars cov
protein protein
endoplasmic reticulum stress
oxidative stress
signaling pathway
amino acid
cell death
multiple sclerosis
cell proliferation
pi k akt
subarachnoid hemorrhage