Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study.
Biljana LakićRanko ŠkrbićSnežana UletilovićNebojša Mandić-KovačevićMilkica GrabežMirna Popović ŠarićMilos P StojiljkovicIvan SoldatovićZorica JanjetovicAnastasija StokanovićNataša StojakovićMomir MikovPublished in: Journal of diabetes research (2024)
The eight-week UDCA administration showed beneficial effects on metabolic and oxidative stress parameters in patients with T2DM. Thus, UDCA could attenuate the progression and complications of diabetes and should be considered as an adjuvant to other diabetes treatment modalities. This trial is registered with NCT05416580.
Keyphrases
- placebo controlled
- double blind
- oxidative stress
- phase iii
- phase ii
- clinical trial
- glycemic control
- study protocol
- type diabetes
- cardiovascular disease
- dna damage
- ischemia reperfusion injury
- phase ii study
- early stage
- diabetic rats
- randomized controlled trial
- open label
- induced apoptosis
- risk factors
- radiation therapy
- signaling pathway
- replacement therapy