Associations of Heavy Metals with Cognitive Function: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.

Yue WeiYan-Feng ZhouLili XiaoJian QinHong ChengHaiqing CaiXing ChenYunfeng ZouLi YangHaiying ZhangZhiyong ZhangXiaobo Yang

Published in: Annals of neurology (2024)

Blood arsenic levels displayed a negative association with the cognitive function of older adults. This finding shows that arsenic-related DNA methylation alterations are critical partial mediators that may serve as potential biomarkers for further mechanism-related studies. ANN NEUROL 2024;96:87-98.

Keyphrases

dna methylation
heavy metals
genome wide
gene expression
drinking water
risk assessment
health risk assessment
physical activity
copy number
social support
sewage sludge