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Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study.

Marwah DoestzadaDaria V ZhernakovaInge C L van den MunckhofDaoming WangAlexander KurilshikovLianmin ChenVincent W BloksMartijn van FaassenJoost H W RuttenLeo A B JoostenMihai G NeteaCisca WijmengaNiels P RiksenAlexandra ZhernakovaFolkert KuipersJingyuan Fu
Published in: BMC medicine (2022)
Our cross-sectional association study reports a large number of associations between BCAAs and CMD parameters. Our results highlight some specific associations for isoleucine, as well as obesity-specific effects for valine. MR-based causality analysis suggests that altered BCAA levels can be a consequence of diabetes and alteration in lipid metabolism. We found no MR evidence to support a causal role for BCAAs in CMD. These findings provide evidence to (re)evaluate the clinical importance of individual BCAAs in CMD diagnosis, prevention, and treatment.
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