Effects of Atrial Fibrillation on the Human Ventricle.
Steffen PabelMaria KnierimThea StehleFelix AlebrandMichael PaulusMarcel SiemeMelissa HerwigFriedrich BarschThomas KörtlArnold PöpplBrisca WennerSenka Ljubojevic-HolzerCristina E MolinaNataliya DybkovaDaniele CamboniThomas H FischerSimon SedejDaniel ScherrChristof SchmidChristoph BrochhausenGerd HasenfussLars Siegfried MaierNazha HamdaniKatrin Streckfuß-BömekeSamuel SossallaPublished in: Circulation research (2022)
AF causes distinct functional and molecular remodeling of the human LV. This translational study provides the first mechanistic characterization and the potential negative impact of AF in the absence of tachycardia on the human ventricle.