The c-Myc-regulated miR-17-92 cluster mediates ATRA-induced APL cell differentiation.

Xibao YuYanyun HuYifan WuChunsheng FangJing LaiShaohua ChenYangqiu Li Chengwu ZengYixin Zeng

Published in: Asia-Pacific journal of clinical oncology (2019)

We report abnormal expression of the miR-17-92 cluster in APL cells, which is responsible for the differentiation block in blast cells in APL. In addition, we identified miR-17-92 as a target gene of c-Myc during ATRA-induced granulocytic differentiation.

Keyphrases

cell proliferation
long non coding rna
induced apoptosis
long noncoding rna
cell cycle arrest
poor prognosis
high glucose
diabetic rats
drug induced
endoplasmic reticulum stress
oxidative stress
transcription factor
genome wide
signaling pathway
gene expression
dna methylation
stress induced