Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease.

Dongmei ChenGuihua LanRuomeng LiYingxue MeiXindong ShuiXi GuLong WangTao ZhangChen-Ling GanYongfang XiaLi HuYuan TianMi ZhangTae Ho Lee

Published in: Translational neurodegeneration (2022)

Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies.

Keyphrases

poor prognosis
cell cycle
cerebrospinal fluid
mouse model
signaling pathway
mild cognitive impairment