KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Boshi WangTiantian JingWeilin JinJinnan ChenChengsi WuMingrong WangYizhen LiuPublished in: Journal of experimental & clinical cancer research : CR (2020)
High expression of KIAA1522 is turned out to be an indicator of dismal effectiveness of platinum-based therapy in lung adenocarcinomas. KIAA1522 hyperactivates TNFα-NFκB signaling to facilitate resistance to platinum reagents. Targeting NFκB signaling through small molecule inhibitors may be a rational strategy to conquer chemoresistance and synergize platinum-based chemotherapy in KIAA1522 overexpressed lung adenocarcinomas.
Keyphrases
- signaling pathway
- small molecule
- lps induced
- rheumatoid arthritis
- oxidative stress
- pi k akt
- nuclear factor
- poor prognosis
- systematic review
- locally advanced
- stem cells
- squamous cell carcinoma
- inflammatory response
- radiation therapy
- cell proliferation
- long non coding rna
- protein protein
- mesenchymal stem cells
- bone marrow