MicroRNA-320a: an important regulator in the fibrotic process in interstitial lung disease of systemic sclerosis.

Yiqun LiJing HuangChaojun HuJiaxin ZhouDong XuYong HouChanyuan WuJiuliang ZhaoMengtao LiXiaofeng ZengChangzheng LiuQian WangYan Zhao

Published in: Arthritis research & therapy (2021)

miR-320a, together with its target genes, TGFBR2 and IGF1R, constituted a complex regulatory network, and played an important role in the fibrotic process of SSc-ILD. Investigation of more detailed mechanisms of miR-320a-mediated regulation of collagen expression may provide new therapeutic strategies for SSc-ILD.

Keyphrases

interstitial lung disease
systemic sclerosis
long non coding rna
cell proliferation
poor prognosis
long noncoding rna
idiopathic pulmonary fibrosis
transcription factor
binding protein
genome wide
rheumatoid arthritis
genome wide identification
signaling pathway
bioinformatics analysis
pulmonary fibrosis