A Multi-mRNA Prognostic Signature for Anti-TNFα Therapy Response in Patients with Inflammatory Bowel Disease.

Suraj SakaramYehudit Hasin-BrumshteinPurvesh Khatri Yudong D HeTimothy E Sweeney

Published in: Diagnostics (Basel, Switzerland) (2021)

Our findings suggest that there is a robust transcriptomic signature for predicting anti-TNFα response in mucosal biopsies from IBD patients prior to treatment initiation. This seven-gene signature should be further investigated for its potential to be translated into a predictive test for clinical use.

Keyphrases

patients with inflammatory bowel disease
rheumatoid arthritis
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
single cell
genome wide
gene expression
copy number
patient reported outcomes
atomic force microscopy
mass spectrometry
combination therapy