Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis.
Sara AsadiParvin FarzanegiMohammad Ali AzarbayjaniPublished in: Physiology international (2020)
Combined therapy with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 genes in the cartilage of rats with knee OA; however, exercise + O3 was significantly more effective.
Keyphrases
- knee osteoarthritis
- mesenchymal stem cells
- high intensity
- poor prognosis
- physical activity
- transcription factor
- stem cells
- resistance training
- umbilical cord
- extracellular matrix
- total knee arthroplasty
- binding protein
- bone marrow
- long non coding rna
- cell therapy
- gene expression
- hydrogen peroxide
- body composition
- genome wide identification
- air pollution
- bioinformatics analysis