Individualized Structural Perturbations on Normative Brain Connectome Restrict Deep Brain Stimulation Outcomes in Parkinson's Disease.

Xuyang WangShiyu FuKwangsun YooXiaoyue WangLin GanTing ZouQing GaoHonghao HanZhenzhe YangXiaofei HuHuafu ChenDingyang LiuRong Li

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

Our findings suggest that individual structural perturbations on the cognitive motor control circuit are critical for modulating DBS outcomes. Interventions toward the circuit have the potential for additional clinical improvements. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

deep brain stimulation
parkinson disease
obsessive compulsive disorder
resting state
physical activity
signaling pathway
functional connectivity
randomized controlled trial
white matter
type diabetes
metabolic syndrome
multiple sclerosis
risk assessment
insulin resistance
subarachnoid hemorrhage