An integrated bioinformatics analysis reveals IRF8 as a critical biomarker for immune infiltration in atherosclerosis advance.
Donglai ZhouTao YuZhi ZhangGuanhua LiYaomin LiPublished in: Clinical and experimental pharmacology & physiology (2024)
Atherosclerosis, a lipid-driven chronic inflammatory disorder, is a significant global health concern associated with high rates of morbidity and mortality, imposing a substantial societal burden. The purpose of this study is to investigate the possible molecular mechanisms of atherosclerosis and identify potential therapeutic targets. We conducted an integrated bioinformatics analysis using data from peripheral blood mononuclear cell and TISSUE databases obtained from the Gene Expression Omnibus, to identify key genes associated with the progression of atherosclerosis. Here, IRF8 was found to be a key gene in atherosclerosis patients. Silencing IRF8 with small interfering RNA reduced inflammation in endothelial cells. This suggests IRF8 is a crucial biomarker for immune infiltration in atherosclerosis advance.
Keyphrases
- cardiovascular disease
- gene expression
- peripheral blood
- dendritic cells
- global health
- endothelial cells
- bioinformatics analysis
- oxidative stress
- end stage renal disease
- dna methylation
- ejection fraction
- single cell
- chronic kidney disease
- machine learning
- genome wide
- type diabetes
- big data
- bone marrow
- prognostic factors
- electronic health record
- risk factors
- patient reported outcomes
- drug induced