Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial.

Igor Makhlin Biniyam G Demissei Ralph B D'Agostino William Gregory Hundley Camelia Baleanu-Gogonea Nicholas S Wilcox Anna Chen Amanda M Smith Nathaniel Sean O'Connell James L Januzzi Glenn J Lesser Marielle Scherrer-Crosbie Francesco Lavarra Wai Hong Wilson Tang Bonnie Ky

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.

Keyphrases

cardiovascular disease
clinical trial
study protocol
stress induced
phase iii
type diabetes
randomized controlled trial
double blind