Zinc Oxide Nanoparticles Exacerbate Epileptic Seizures by Modulating the TLR4-Autophagy Axis.
Pingyang KeJing LiuChengzhi ChenSen LuoHuiwen GuJuan GuYan LiuYuanlin MaYuan MengLiqin HuXin TianFei XiaoPublished in: International journal of nanomedicine (2024)
ZnO NPs enhanced the susceptibility and severity of epilepsy. Mechanistically, ZnO NPs affected autophagy by changing the expression of TLR4. In particular, the ZnO NPs mainly affected the synaptic function of inhibitory neuron, leading to excitation/inhibition imbalances.
Keyphrases
- oxide nanoparticles
- room temperature
- quantum dots
- signaling pathway
- toll like receptor
- cell death
- inflammatory response
- reduced graphene oxide
- endoplasmic reticulum stress
- immune response
- visible light
- poor prognosis
- oxidative stress
- light emitting
- nuclear factor
- energy transfer
- ionic liquid
- gold nanoparticles
- prefrontal cortex