Safety and tolerability of a single infusion of autologous ex vivo expanded regulatory T cells in adults with ulcerative colitis (ER-TREG 01): protocol of a phase 1, open-label, fast-track dose-escalation clinical trial.

Caroline J VoskensDiane StoicaSusanne RoessnerFrancesco VitaliSebastian ZundlerMarita RosenbergManuel WiesingerJutta WunderBritta SiegmundBeatrice Schuler-ThurnerGerold SchulerCarola BerkingRaja AtreyaMarkus F Neurath

Published in: BMJ open (2021)

NCT04691232.

Keyphrases

open label
regulatory t cells
ulcerative colitis
clinical trial
phase ii
phase iii
phase ii study
dendritic cells
study protocol
randomized controlled trial
bone marrow
low dose
cell therapy
endoplasmic reticulum
estrogen receptor
breast cancer cells
platelet rich plasma
squamous cell carcinoma
immune response