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PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer.

Fahad Shabbir AhmedPatricia GauleJohn McGuireKatir PatelKim R M BlenmanLajos PusztaiDavid L Rimm
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Expression of PD-L1 in tumor cells, immune cells in stroma, and colocalized with CD68+ cells is associated with higher rates of pCR to durvalumab and chemotherapy in TNBC.
Keyphrases
  • locally advanced
  • rectal cancer
  • induced apoptosis
  • poor prognosis
  • cell cycle arrest
  • squamous cell carcinoma
  • radiation therapy
  • endoplasmic reticulum stress
  • chemotherapy induced
  • real time pcr